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M94A2377.TXT
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1994-10-25
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Document 2377
DOCN M94A2377
TI Natural history of HIV-1 infection among injecting drug users.
DT 9412
AU Siddiqui N; Brown LS; Meyer TJ; Addiction Research and Treatment
Corporation, Brooklyn, NY 11201.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):318 (abstract no. PC0202). Unique
Identifier : AIDSLINE ICA10/94370198
AB OBJECTIVE: To evaluate the natural history of HIV-1 infection among
injecting drug users (IDU) attending a methadone maintenance program in
New York City (NYC). METHODS: Between December 1988 and August 1991, 350
HIV-1 infected IDU were enrolled in a natural history study. Baseline
and follow-up assessments including information regarding
sociodemographic characteristics, HIV related symptomatology, drug use,
sexual practices, and laboratory studies. RESULTS: The study sample was
nearly two-thirds male, predominantly African American and Latino, and
had a mean age of 37 years. The Kaplan-Meier plot showed that subjects
with a baseline CD4 count of less than 200 had shorter survival times (p
< .001). Race/ethnicity was not related to survival. Married
participants had longer survival times (p < .05). Baseline CD8 levels
independently predicted survival (cut point 300). Higher scores on
HIV-disease-related symptoms scale were associated with shorter survival
time (p < .001). Decreasing levels of CD4 cells and increasing levels of
Beta-2-macroglobulin over time also predicted survival, even when
adjusted for baseline CD4 levels (p < .05). DISCUSSION: This report
describes natural history of HIV-1 infection among NYC IDU in a
non-hospital study setting which may provide a more realistic assessment
than controlled clinical trials. Supported by NIDA.
DE Adult Female Human HIV Infections/*COMPLICATIONS *HIV-1 Male
Substance Abuse, Intravenous/*COMPLICATIONS Support, U.S. Gov't, P.H.S.
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).